During　the　1995　Kobe　earthquake　in　Japan,　the　Daikai　subway　station　suffered　total　collapse,　which　made　the　research　on　the　seismic　failure　mechanism　of　underground　frame　structures　become　a　hot　topic.　The　author　has　carried　out　a　lot　of　research　on　earthquake　failure　mechanism　of　underground　frame　structures　based　on　numerical　method.　To　validate　and　further　study　the　seismic　failure　response　and　mechanism　of　underground　frame　structures,　a　series　of　comparative　dynamic　centrifuge　tests　were　carried　out.　The　research　conclusions　are　as　follows.　The　vertical　earthquake　action　significantly　increased　the　axial　pressure　on　the　columns　of　an　underground　frame　structure,　reducing　their　horizontal　deformation　capacity.　The　columns　subjected　to　high　axial　compression　were　prone　to　brittle　damage　under　a　relatively　strong　horizontal　earthquake,　which　led　to　the　overall　collapse　of　an　underground　frame　structure.　The　areas　near　the　intersection　of　the　ceiling　slab　and　the　sidewalls　were　the　weak　part　of　the　underground　frame　structure　and　were　vulnerable　to　tensile　cracks　under　earthquake.　The　columns＇　top　and　bottom　were　the　fragile　parts　and　were　prone　to　concrete　cracking　or　even　shear　failure　under　an　earthquake.　If　the　columns　could　remain　intact　and　effectively　provided　vertical　support　under　a　strong　earthquake,　it　was　beneficial　to　reduce　the　risk　of　the　overall　collapse　of　an　underground　frame　structure.