Human　papilloma　virus　(HPV)　is　a　serious　threat　to　human　life　globally　with　over　100　genotypes　including　cancer　causing　high　risk　HPVs.　Study　on　protein　interaction　maps　of　pathogens　with　their　host　is　a　recent　trend　in　＇omics＇　era　and　has　been　practiced　by　researchers　to　find　novel　drug　targets.　In　current　study,　we　construct　an　integrated　protein　interaction　map　of　HPV　with　its　host　human　in　Cytoscape　and　analyze　it　further　by　using　various　bioinformatics　tools.　We　found　out　2988　interactions　between　12　HPV　and　2061　human　proteins　among　which　we　identified　MYLK,　CDK7,　CDK1,　CDK2,　JAK1　and　6　other　human　proteins　associated　with　multiple　viral　oncoproteins.　The　functional　enrichment　analysis　of　these　top-notch　key　genes　is　performed　using　KEGG　pathway　and　Gene　Ontology　analysis,　which　reveals　that　the　gene　set　is　enriched　in　cell　cycle　a　crucial　cellular　process,　and　the　second　most　important　pathway　in　which　the　gene　set　is　involved　is　viral　carcinogenesis.　Among　the　viral　proteins,　E7　has　the　highest　number　of　associations　in　the　network　followed　by　E6,　E2　and　E5.　We　found　out　a　group　of　genes　which　is　not　targeted　by　the　existing　drugs　available　for　HPV　infections.　It　can　be　concluded　that　the　molecules　found　in　this　study　could　be　potential　targets　and　could　be　used　by　scientists　in　their　drug　design　studies.