The　development　of　new　heterogeneous　Cu-based　solid　catalysts　for　hydroxyl　radical　(center　dot　OH)　generation　plays　a　crucial　role　in　degradation　of　pollutants　at　neutral　pH　circumstance.　In　this　work,　a　Cu-doped　graphitic　carbon　nitride　(g-C3N4)　complex　was　synthesized　in　one-step　pyrolysis　process　using　copper　chloride　dihydrate　and　dicyandiamide　as　precursors.　The　results　reveal　that　after　Cu　doping,　the　bulk　structure　of　g-C3N4　was　destroyed　with　fragmentary　morphology　formation.　Besides,　Cu-0　and　Cu+　were　successfully　embedded　in　g-C3N4　sheet.　Moreover,　amoxicillin　(AMX)　removal　by　heterogeneous　electro-Fenton　process　was　performed　to　evaluate　the　catalytic　activity　of　the　Cu-doped　g-C3N4.　99.1%　AMX　removal　efficiency　was　obtained　after　60　min　electrolysis　under　neutral　pH　condition　when　the　current　density　was　12　mA　cm(2)　and　the　catalyst　dosage　was　0.3　g　L-1.　Both　Cu-0　and　Cu+　were　stably　retained　in　the　Cu-doped　g-C3N4　catalyst　and　AMX　removal　efficiency　reached　91.1%,　even　after　5　cycles,　manifesting　the　remarkable　stability　of　Cu-doped　g-C3N4.　Also,　Cu-doped　g-C3N4　possessed　excellent　catalytic　activities　for　AMX　removal　in　various　waterbodies.　According　to　the　catalytic　mechanism　analysis,　the　center　dot　OH　was　proved　to　be　the　primary　reactive　species　for　AMX　removal　in　heterogeneous　electro-Fenton　process.　Based　on　the　identification　of　sixteen　different　intermediate　products,　the　possible　degradation　pathways　were　proposed.　This　work　provides　a　simple　method　to　synthesize　a　Cu-based　solid　catalyst　containing　stable　Cu-0　and　Cu+　for　degradation　of　pollutants　in　wastewater.