In　this　paper,　a　molecular　dynamics　(MD)-based　multiscale　analysis　is　employed　to　investigate　the　free　vibration　of　graphene　reinforced　laminated　composite　plates　from　the　atomic　scale　to　the　macroscopic　behavior.　The　atomic　models　of　graphene　with　different　sizes,　poly　(methyl　methacrylate)　(PMMA)　and　graphene/PMMA　composites　with　different　graphene　volume　fractions　are　constructed,　and　Poisson＇s　ratio　as　well　as　elastic　moduli　are　in　good　agreements　with　the　MD　results.　Then　the　efficiency　parameters　of　the　Young＇s　and　shear　moduli　of　graphene/PMMA　composites　are　derived　at　the　micro　scale　via　the　extended　Halpin-Tsai　micromechanics　model,　and　are　employed　subsequently　to　the　vibration　analysis　at　the　macro　scale.　Based　on　the　first　order　shear　deformation　theory　and　meshless　method,　the　governing　equation　of　functionally　graded　graphene　reinforced　composite　(FG-GRC)　quadrilateral　plates　is　derived　and　discretized　to　analyze　the　vibration　behavior.　The　effects　of　geometrical　parameter,　graphene　volume　fraction　and　distribution　pattern　are　investigated　on　the　dimensionless　frequency　of　FG-GRC　quadrilateral　plates.　The　multiscale　analysis　in　this　paper　combines　the　simulation　of　material　properties　at　the　atomic　scale　and　the　response　of　structure　at　the　macro　scale,　which　provides　a　feasible　way　to　study　the　vibration　behavior　of　composite　structures.　(c)　2021　Elsevier　Inc.　All　rights　reserved.