In　this　study,　a　new　sulfidated　nanoscale　zero　valent　iron　(S-nZVI)　supported　on　hydrogel　(S-nZVI@H)　was　successfully　synthesized　for　the　removal　of　Cr(VI)　from　groundwater.　The　surface　morphology,　dispersion　phenomenon　and　functional　groups　of　novel　S-nZVI@H　were　characterized　by　scanning　electron　microscopy　(SEM)　and　Fourier　transform　infrared　spectroscopy　(FTIR).　Box-Behnken　design　(BBD)　optimization　technology　based　on　response　surface　methodology　(RSM)　is　applied　to　demonstrate　the　influence　of　the　interaction　of　S-nZVI@H　dose,　initial　Cr(VI)　concentration,　contact　time,　and　initial　pH　with　the　Cr(VI)　removal　efficiency.　The　AVOVA　results　(F　=　118.73,　P　＜　0.0001,　R-2　=　0.9916)　show　that　the　quadratic　polynomial　model　is　significant　enough　to　reflect　the　close　relationship　between　the　experimental　and　predicted　values.　The　predicted　optimum　removal　conditions　are　determined　to　be　as　follows:　S-nZVI@H　dose　9.46　g/L,　initial　Cr(VI)　concentration　30　mg/L,　contact　time　40.7　min　and　initial　pH　5.27,　and　the　S-nZVI@H　dose　is　the　key　factor　affecting　the　removal　of　Cr(VI).　The　predicted　value　(99.76%)　of　Cr　(VI)　removal　efficiency　is　in　good　agreement　with　the　experimental　value　(97.75%),　which　verifies　the　validity　of　the　quadratic　polynomial　model.　This　demonstrates　that　RSM　with　appropriate　BBD　can　be　considerably　utilized　to　optimize　the　design　of　experiments　for　removal　of　Cr(VI).