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Author：

Yan, Jiayi (Yan, Jiayi.) | Ruan, Panpan (Ruan, Panpan.) | Ge, Yunxuan (Ge, Yunxuan.) | Gao, Jing (Gao, Jing.) | Tan, Hongling (Tan, Hongling.) | Xiao, Chengrong (Xiao, Chengrong.) | Gao, Quansheng (Gao, Quansheng.) | Zhang, Zhuo (Zhang, Zhuo.) | Gao, Yue (Gao, Yue.)

Indexed by：

Scopus SCIE

Abstract：

Compound　Danshen　dropping　pill　(CDDP),　a　famous　Chinese　medicine　formula,　has　been　widely　used　to　treat　high-altitude　heart　disease　in　China.　However,　its　molecular　mechanisms,　potential　targets,　and　bioactive　ingredients　remain　elusive.　In　this　study,　network　pharmacology,　molecular　docking,　and　validation　experiments　were　combined　to　investigate　the　effective　active　ingredients　and　molecular　mechanisms　of　CDDP　in　the　treatment　of　high-altitude　heart　disease.　Tan　IIA　may　be　the　main　active　component　of　CDDP　in　the　treatment　of　high-altitude　heart　disease　via　HIF-1/PI3K/Akt　pathways.

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Author Community：

  • [ 1 ] [Yan, Jiayi]Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Peoples R China
  • [ 2 ] [Gao, Yue]Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Peoples R China
  • [ 3 ] [Yan, Jiayi]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
  • [ 4 ] [Ruan, Panpan]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
  • [ 5 ] [Ge, Yunxuan]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
  • [ 6 ] [Gao, Jing]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
  • [ 7 ] [Tan, Hongling]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
  • [ 8 ] [Xiao, Chengrong]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
  • [ 9 ] [Zhang, Zhuo]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
  • [ 10 ] [Gao, Yue]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China
  • [ 11 ] [Ruan, Panpan]Heibei Univ, Sch Life Sci, Baoding 071000, Peoples R China
  • [ 12 ] [Ge, Yunxuan]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 13 ] [Gao, Jing]Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China
  • [ 14 ] [Gao, Quansheng]Acad Mil Med Sci, Acad Mil Med Sci, Inst Enviromental & Operat Med, Tianjin 300381, Peoples R China

Reprint Author's Address：

  • [Gao, Yue]Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Peoples R China;;[Zhang, Zhuo]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China;;[Gao, Yue]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing 100850, Peoples R China

Email：


zhangzhuo000@yeah.net |
gaoyue@bmi.ac.cn
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Source ：

ACS OMEGA

ISSN： 2470-1343

Year： 2021

Issue： 41

Volume： 6

Page： 26942-26951

4 . 1 0 0

JCR@2022

JCR Journal Grade：2

Cited Count：

WoS CC Cited Count： 5

SCOPUS Cited Count： 5

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 7

Affiliated Colleges：

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