In　the　development　process　of　intelligent　construction,　the　safety　assessment　of　prestressed　steel　structures　as　an　important　research　direction　has　become　more　and　more　attractive　in　academia.　Digital　twins　(DTs)　is　the　key　technology　to　realize　intelligent　construction.　The　virtual　and　real　interaction　of　the　DTs　can　provide　an　efficient　management　and　control　mechanism　for　the　construction　process.　This　research　proposes　an　intelligent　safety　assessment　method　of　prestressed　steel　structures　based　on　DTs.　In　this　research　method,　the　structural　safety　assessment　is　divided　into　two　aspects:　performance　analysis　and　maintenance.　By　analyzing　the　characteristics　of　the　construction　safety　assessment,　a　DTs　framework　for　construction　safety　assessment　is　built.　Driven　by　the　DTs　framework,　a　physical　space　model　and　a　virtual　space　model　are　constructed.　On　the　basis　of　virtual　and　actual　interaction,　multidimensional　information　fusion　of　time　and　space　is　carried　out　to　realize　the　analysis　of　structural　safety　performance.　On　this　basis,　the　paper　establishes　a　Bow-tie　model　for　the　maintenance　modeling　of　unsafe　construction　events.　Moreover,　the　theoretical　method　formed　is　applied　to　the　construction　of　a　symmetrical　structure　(wheel-spoke　cable　truss).　The　validity　of　the　method　is　verified　by　comparing　the　cable　force　calculated　by　the　theoretical　method　and　measured　on　site.　The　assessment　method　driven　by　the　DTs　ensures　the　structural　safety　and　improves　the　intelligence　level　of　safety　management　and　control　of　the　structure　construction.