• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
搜索

Author:

Kang, Wenjie (Kang, Wenjie.) | Lin, Lan (Lin, Lan.) | Zhang, Baiwen (Zhang, Baiwen.) | Shen, Xiaoqi (Shen, Xiaoqi.) | Wu, Shuicai (Wu, Shuicai.) (Scholars:吴水才)

Indexed by:

EI Scopus SCIE

Abstract:

Alzheimer's Disease (AD) is a chronic neurodegenerative disease without effective medications or supplemental treatments. Thus, predicting AD progression is crucial for clinical practice and medical research. Due to limited neuroimaging data, two-dimensional convolutional neural networks (2D CNNs) have been commonly adopted to differentiate among cognitively normal subjects (CN), people with mild cognitive impairment (MCI), and AD patients. Therefore, this paper proposes an ensemble learning (EL) architecture based on 2D CNNs, using a multi model and multi-slice ensemble. First, the top 11 coronal slices of grey matter density maps for AD versus CN classifications were selected. Second, the discriminator of a generative adversarial network, VGG16, and ResNet50 were trained with the selected slices, and the majority voting scheme was used to merge the multi-slice decisions of each model. Afterwards, those three classifiers were used to construct an ensemble model. Multi-slice ensemble learning was designed to obtain spatial features, while multi-model integration reduced the prediction error rate. Finally, transfer learning was used in domain adaptation to refine those CNNs, moving them from working solely with AD versus CN classifications to being applicable to other tasks. This ensemble approach achieved accuracy values of 90.36%, 77.19%, and 72.36% when classifying AD versus CN, AD versus MCI, and MCI versus CN, respectively. Compared with other state-of-the-art 2D studies, the proposed approach provides an effective, accurate, automatic diagnosis along the AD continuum. This technique may enhance AD diagnostics when the sample size is limited.

Keyword:

Convolutional neural networks Deep learning Generative adversarial networks Alzheimer's disease Mild cognitive impairment Structural MRI

Author Community:

  • [ 1 ] [Kang, Wenjie]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China
  • [ 2 ] [Lin, Lan]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China
  • [ 3 ] [Zhang, Baiwen]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China
  • [ 4 ] [Shen, Xiaoqi]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China
  • [ 5 ] [Wu, Shuicai]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China

Reprint Author's Address:

  • [Lin, Lan]Beijing Univ Technol, Fac Environm & Life Sci, Dept Biomed Engn,Beijing Int Platform Sci & Techn, Intelligent Physiol Measurement & Clin Translat, Beijing 100124, Peoples R China

Show more details

Related Keywords:

Related Article:

Source :

COMPUTERS IN BIOLOGY AND MEDICINE

ISSN: 0010-4825

Year: 2021

Volume: 136

7 . 7 0 0

JCR@2022

ESI Discipline: COMPUTER SCIENCE;

ESI HC Threshold:87

JCR Journal Grade:1

Cited Count:

WoS CC Cited Count: 78

SCOPUS Cited Count: 100

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 9

Online/Total:637/10516734
Address:BJUT Library(100 Pingleyuan,Chaoyang District,Beijing 100124, China Post Code:100124) Contact Us:010-67392185
Copyright:BJUT Library Technical Support:Beijing Aegean Software Co., Ltd.