Cadmium　(Cd)　could　reduce　abnormal　cell　morphology　and　membrane　permeability,　however,　there　are　few　studies　on　the　detoxification　of　Cd-reduced　cell　membrane　toxicity.　In　the　present　study,　we　firstly　studied　the　effects　of　zinc　chloride　(ZnCl2),　n-acetyl-L-cysteine　(NAC),　and　calcium/calmodulin　dependent　protein　kinase　II　inhibitor　(KN93)　on　cell　membrane　permeability,　respectively;　then,　we　studied　the　inhibitory　effects　of　ZnCl2,　NAC,　and　KN93　on　Cd2+-induced　abnormal　cell　membrane　permeability　by　scanning　electrochemical　microscopy　(SECM)　scanning　imaging,　transverse　scanning　curve　and　DPV　technology.　Our　results　showed　that　10　mu　moll　L-1　ZnCl2,　0.5　mmoll　L-1　NAC　and　5　mu　moll　L-1　KN93　could　significantly　improve　the　activity　of　MCF-7　cells,　while　did　not　destroy　the　cell　morphology　and　membrane　permeability.　0.5　mmoll　L-1　NAC　and　5　mu　moll　L-1　KN93　could　significantly　inhibit　the　effects　of　Cd2+　on　the　morphology　and　membrane　permeability　of　MCF-7　cells　(p　＜　0.01).10　mu　moll　L-1　ZnC2　could　significantly　inhibit　the　effect　of　Cd　on　the　membrane　permeability　of　MCF-7　cells,　however,　it　cannot　completely　eliminate　the　morphological　changes　of　MCF-7　cells　caused　by　Cd2+.　The　results　of　cell　activity　experiment　showed　that　10　mu　moll　L-1　ZnCl2,　0.5　mmoll　L-1　NAC　and　5　mu　mollL-1　KN93　could　inhibit　the　effect　of　Cd2+　on　the　activity　of　MCF-7　cells.　By　comparing　the　inhibitory　effects　of　ZnCl2,　NAC　and　KN93　on　Cd2+-　induced　cytotoxicity,　5　mu　moll　L-1　KN93　had　the　robust　effect　on　the　maintenance　of　MCF-7　cell　morphology　and　cell　membrane　integrity.　Our　research　provided　evidence　on　Zn　supplement,　NAC　as　antioxidant　drugs,　and　KN93　as　special　inhibitor　for　the　detoxification　of　Cd2+-reduced　abnormal　cell　morphology　and　membrane　permeability.