In　order　to　alleviate　bus　bunching　and　improve　the　balance　and　punctuality　rate　of　bus　operation,　a　single-line　real-time　control　strategy　based　on　Intelligent　Transportation　System　(ITS)　was　proposed.　The　strategy　took　three　measures:　controlling　the　cruising　speed,　dwell　time,　and　the　bus　load　rate　to　improve　the　stability　of　bus　operations　and　to　ensure　its　running　speed.　At　the　same　time,　the　proposed　strategy　was　compared　with　the　literature　on　the　traditional　single-point　control　strategy　based　on　timetable　(S1　for　short)　and　the　multi-point　control　strategy　based　on　time　headway　(S2　for　short).　Finally,　the　No.　245　bus　line　in　Nanchang　City,　China,　was　selected　as　a　case.　It　was　modeled　and　simulated　by　Python　programming　software,　and　the　control　effects　of　the　three　control　strategies　were　analyzed.　Compared　with　the　uncontrolled　bus　operations,　the　simulation　results　show　that:　under　the　control　of　S1,　the　bus　operation　stability　is　improved,　but　the　bus　operation　efficiency　is　reduced;　under　the　control　of　S2,　the　problem　of　S1　operation　efficiency　reduction　can　be　solved,　and　the　operation　stability　can　be　improved　at　the　same　time　to　achieve　the　effect　of　preventing　bunching.　For　the　real-time　control　strategy　(S3　for　short),　the　average　bus　travel　time　is　the　smallest,　the　distance　between　the　buses　is　maintained　the　best,　and　the　running　stability　is　also　the　best,　which　avoids　the　bus　bunching　to　the　greatest　extent.　Among　them,　the　average　travel　time　is　reduced　by　about　34%　compared　with　the　second　strategy.　This　study　provides　a　theoretical　basis　and　strategy　reference　for　bus　operators　to　ensure　balanced　bus　operation.