Anaerobic　digestion　centrate　produced　from　thermal　hydrolysis　pretreated　sludge　(THP-AD　centrate)　has　serious　inhibitory　effect　on　ammonium　oxidizing　bacteria　(AOB)　and　anammox　bacteria.　This　imposes　huge　challenge　to　employ　partial　nitritation/anammox　(PN/A)　process　to　treat　THP-AD　centrate.　This　study,　for　the　first　time,　presented　an　effective　strategy,　ozone　pretreatment,　to　alleviate　such　inhibitory　effect.　The　activities　of　AOB　and　anammox　bacteria　increased　with　increasing　ozone　dosage,　which　were　likely　related　to　the　transformation　of　organic　compounds　including　humic　acid-like　and　fulvic　acid-like　substances　as　well　as　high　molecular　weight　(HMW)　protein.　Long-term　operation　of　PN/A　system　further　demonstrated　the　improved　performance　in　term　of　nitrogen　removal,　organics　degradation　as　well　as　sludge　settleability　and　effluent　solids.　Nitrogen　removal　rate　(NRR)　of　0.64　Kg　N/m(3)/d　was　achieved　(1.38　g　O-3/　g　COD),　which　was　42.2%　higher　compared　to　treating　untreated　THP-AD　centrate.　Effluent　nitrate,　the　by-product　of　PN/A　process,　was　reduced　by　39.7%　despite　of　its　release　in　ozonation.　This　was　due　to　the　enhanced　denitrification　activity,　humic　acid-like　and　fulvic　acid-like　substances　as　well　as　HMW　protein　were　significantly　reduced.　Overall,　this　study　provides　a　promising　method　to　improve　PN/A　performance　and　final　effluent　quality　when　treating　organic-rich　THP-AD　centrate.