The　recent　development　of　water-stable　metal-organic　frameworks　(MOFs)　has　significantly　broadened　the　application　scope　of　this　emerging　type　of　porous　material.　Structure　tuning　of　hafnium　MOFs　is　less　studied　compared　with　zirconium　MOFs.　In　this　work,　we　report　the　synthesis　of　a　mesoporous　hafnium　MOF,　csq-MOF-1,　through　finely　tuning　the　solvent　mixture　ratio.　The　successful　synthesis　of　csq-MOF-1　also　relies　on　the　linker　flexibility　as　linker　bending　and　a　symmetry　decrease　were　observed　in　this　framework　as　compared　to　its　structural　isomer　NPF-300　(Hf).　The　mesoporous　feature　and　permanent　porosity　were　determined　by　the　N-2　adsorption　at　77　K.　Such　a　hierarchical　pore　feature　is　expected　to　enable　a　variety　of　applications　through　encapsulation　of　large　functional　molecules.　The　synthetic　strategy　of　utilizing　a　mixed　solvent　and　flexible　linker　is　expected　to　inspire　the　development　of　new　hafnium　MOFs　with　diverse　topological　structures.