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Author:

Fang, Jui (Fang, Jui.) | Lai, Ming-Wei (Lai, Ming-Wei.) | Cheng, Hao-Tsai (Cheng, Hao-Tsai.) | Cristea, Anca (Cristea, Anca.) | Zhou, Zhuhuang (Zhou, Zhuhuang.) | Tsui, Po-Hsiang (Tsui, Po-Hsiang.)

Indexed by:

Scopus SCIE

Abstract:

Hepatic steatosis causes nonalcoholic fatty liver disease. Whole-body vibration (WBV) has been recommended to allow patients who have difficulty engaging in exercise to improve the grade of hepatic steatosis. This study proposed using ultrasound parametric imaging of the homodyned K (HK) distribution to evaluate the effectiveness of WBV treatments in alleviating hepatic steatosis. Sixty mice were assigned to control (n = 6), sedentary (n = 18), WBV (n = 18), and exercise (swimming) (n = 18) groups. Mice were fed a high-fat diet to induce hepatic steatosis and underwent the intervention for 4, 8, and 16 weeks. Ultrasound scanning was performed in vivo on each mouse after the interventions for ultrasound HK imaging using the parameter mu (the scatterer clustering parameter). Histopathological examinations and the intraperitoneal glucose tolerance test were carried out for comparisons with ultrasound findings. At the 16th week, WBV and exercise groups demonstrated lower body weights, glucose concentrations, histopathological scores (steatosis and steatohepatitis), and mu parameters than the control group (p < 0.05). The steatosis grade was significantly lower in the WBV group (mild) than in the exercise group (moderate) (p < 0.05), corresponding to a reduction in the mu parameter. A further analysis revealed that the correlation between the steatosis grade and the mu parameter was 0.84 (p < 0.05). From this animal study we conclude that WBV may be more effective than exercise in reducing the progression of hepatic steatosis, and ultrasound HK parametric imaging is an appropriate method for evaluating WBV's effect on hepatic steatosis.

Keyword:

whole-body vibration hepatic steatosis ultrasound envelope statistics

Author Community:

  • [ 1 ] [Fang, Jui]China Med Univ Hosp, X Dimens Ctr Med Res & Translat, Taichung 404332, Taiwan
  • [ 2 ] [Lai, Ming-Wei]Chang Gung Mem Hosp Linkou, Liver Res Ctr, Dept Pediat, Div Pediat Gastroenterol, Taoyuan 333423, Taiwan
  • [ 3 ] [Tsui, Po-Hsiang]Chang Gung Mem Hosp Linkou, Liver Res Ctr, Dept Pediat, Div Pediat Gastroenterol, Taoyuan 333423, Taiwan
  • [ 4 ] [Cheng, Hao-Tsai]Chang Gung Mem Hosp Linkou, Dept Gastroenterol & Hepatol, Taoyuan 333423, Taiwan
  • [ 5 ] [Cheng, Hao-Tsai]New Taipei Municipal Tucheng Hosp, Dept Gastroenterol & Hepatol, New Taipei 236017, Taiwan
  • [ 6 ] [Cristea, Anca]UiT Arctic Univ Norway, Dept Phys & Technol, N-9019 Tromso, Norway
  • [ 7 ] [Zhou, Zhuhuang]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 8 ] [Tsui, Po-Hsiang]Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan 333323, Taiwan

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Source :

PHARMACEUTICS

Year: 2022

Issue: 4

Volume: 14

5 . 4

JCR@2022

5 . 4 0 0

JCR@2022

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count: 1

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 6

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