Metal-organic　frameworks　(MOFs)　have　recently　achieved　much　attention　to　eliminating　toxic　pol-lutants　because　of　their　attractive　attributes,　including　large　specific　surface　area,　ultra-high　porosity,　abundant　active　adsorption　sites,　tunable　surface　chemistry,　well-controlled　pore　size　distribution,　and　strong　host-guest　interactions.　Among　the　many　developed　MOFs,　the　Zr-based　MOFs,　particularly　the　UiO-66　family,　are　considered　extremely　attractive　for　wastewater　treatment　applications.　The　fascinating　properties　of　UiO-66　such　as　high　thermal　stability,　superior　chemical　resistance　towards　several　solvents,　including　benzene,　acetone,　different　alcohols,　dimethylformamide,　acidic　and　basic　solution,　excellent　chemical　stability　against　various　conditions　such　as　air,　water,　and　chloroform,　and　exceptional　resistance　to　high　external　pressure,　mainly　due　to　strong　Zr-O　bond　and　high　coordination　number　between　the　Zr　clusters　and　organic　ligands　have　led　to　numerous　potential　applications　in　wastewater　treatment.　This　review　primarily　focuses　on　the　latest　efforts　in　applying　UiO-66　MOFs　as　superior　water-stable　MOFs　for　efficient　removal　(adsorption/separation　and　degradation/reduction)　of　various　water　pollutants,　including　organic　dyes,　heavy　metal　ions,　pharmaceuticals　and　personal　care　products,　phosphate,　and　fluoride.　The　possible　adsorption/separation　and　degradation/reduc-tion　mechanisms　for　removing　water　pollutants　by　UiO-66　and　its　modified　derivatives　are　fully　addressed.　Thus,　the　review　is　expected　to　provide　guidance　and　stimulate　researchers　to　carefully　investigate　the　real　applications　of　UiO-66　MOFs　in　water　and　wastewater　treatment　applications.