The　design　of　ventilation　system　has　implications　for　the　safety　of　life　and　property,　and　the　development　of　regulations　and　standards　in　the　space　with　the　hydrogen　storage　equipment.　The　impact　of　both　the　position　and　the　area　of　a　single　vent　on　the　dispersion　of　hydrogen　in　a　cuboid　space　(with　dimensions　L　x　W　x　H　=　2.90　x　0.74　x　1.22　m)　is　investigated　with　Computational　Fluid　Dynamics　(CFD)　in　this　study.　Nine　positions　of　the　vent　were　compared　for　the　leakage　taking　place　at　the　floor　to　understand　the　gas　dispersion.　It　was　shown　a　cloud　of　1%　mole　fraction　has　been　formed　near　the　ceiling　of　the　space　in　less　than　40　s　for　different　positions　of　the　vent,　which　can　activate　hydrogen　sensors.　The　models　show　that　the　hydrogen　is　removed　more　effectively　when　the　vent　is　closer　to　the　leakage　position　in　the　horizontal　direction.　The　study　demonstrates　that　the　vent　height　of　1.00　m　is　safer　for　the　particular　scenario　considered.　The　area　of　the　vent　has　little　effect　on　the　hydrogen　concentration　for　all　vent　positions　when　the　area　of　the　vent　is　less　than　0.045　m(2)　and　the　height　of　the　vent　is　less　than　0.61　m.　(C)　2022　The　Authors.　Published　by　Elsevier　Ltd　on　behalf　of　Hydrogen　Energy　Publications　LLC.