The　nonlinear　monopile-soil　dynamic　response　supporting　an　offshore　wind　turbine　subjected　to　wind　and　waves　in　two　multi-layered　soil　sites　in　the　Arabian　Sea　are　numerically　analyzed　in　this　work.　Based　on　the　numerical　simulation,　the　impact　of　soil　parametric　variation　in　the　near-pile　soil　region,　variation　in　soil　layering,　pile　diameters,　pile　wall　thicknesses,　sediment　effect,　variation　in　sea　water　depth　and　variation　of　wave　and　wind　heights　have　been　particularly　emphasized　in　the　frequency　domain　employing　PISA　design　model.　Numerical　predictions　for　translational　and　rotational　impedances　with　Fourier　response　amplitude　compatibility　have　been　investigated　and　verified　using　DynaN　and　Abaqus.　The　design　optimization　of　soil-pile　interaction　up　to　onethird　embedded　depth　is　heavily　influenced　by　changes　in　soil　layer　pattern　and　sedimentation.　The　results　reveal　that　as　the　pile　diameter　and　wall　thickness　rise,　the　dynamic　impedance　increases　both　horizontally　and　vertically　as　the　pile　approaches　its　tip.　Subsequently,　a　parametric　analysis　and　finite　differences　study　are　conducted　to　get　insight　into　monopile-soil　behavior　by　examining　various　mesh　sizes,wave　and　wind　heights　effects.　Finally,　the　validity　results　show　that　PISA　model　can　be　extended　to　a　complex　marine　layered　soil　profiles　with　larger　length　-to-diameter　(L/D)　and　diameter-to-pile　wall　thickness　(D/t)　ratio　to　get　sound　economic　benefits　in　the　future.