BACKGROUND:　Gestational　diabetes　mellitus　(GDM)　is　a　metabolic　disease　that　seriously　endangers　the　health　of　mothers　and　children.　It　is　important　to　monitor　GDM　in　real-time　before　diagnosis　and　to　prevent　it　effectively.　OBJECTIVE:　GDM　was　divided　into　the　second　trimester　diagnosed　diabetes　mellitus　(GDM_24)　and　the　third　trimester　diagnosed　diabetes　mellitus　(GDM_30).　The　risk　prediction　of　two　types　of　GDM　was　performed　in　normal　pregnant　women　at　11-13　and　16-19　weeks　of　pregnancy,　respectively.　METHODS:　By　stages,　the　K-W　test　was　used　to　analyze　the　differences　between　basic　information　and　energy　metabolism　factors,　and　multiple　logistic　regression　was　used　to　analyze　the　risk　of　energy　metabolism　factors　and　to　correct　the　confounders　with　significant　differences.　RESULTS:　For　the　GDM_24　group,　each　additional　unit　of　oxygen　consumption　(VO2),　carbon　dioxide　production,　and　resting　energy　expenditure　(REE)　increased　the　risk　by　2.4%,　3.5%,　0.4%,　and　2.1%,　2.6%,　and　0.3%,　respectively,　at　11-13　and　16-19　weeks　of　pregnancy.　For　the　GDM_30　group,　each　additional　unit　of　VO2　and　REE　was　associated　with　an　increased　risk　of　2.3%　and　0.3%,　respectively,　at　16-19　weeks　of　pregnancy.　CONCLUSION:　The　risk　of　GDM_30　only　appeared　in　pregnant　women　during　16-19　weeks　of　pregnancy,　which　may　indicate　that　GDM_24　and　GDM_30　have　different　pathogenesis.