The　relatively　limited　understanding　of　the　physiology　of　uterine　activation　prevents　us　from　achieving　optimal　clinical　outcomes　for　managing　serious　pregnancy　disorders　such　as　preterm　birth　or　uterine　dystocia.　There　is　increasing　awareness　that　multi-scale　computational　modeling　of　the　uterus　is　a　promising　approach　for　providing　a　qualitative　and　quantitative　description　of　uterine　physiology.　The　overarching　objective　of　such　approach　is　to　coalesce　previously　fragmentary　information　into　a　predictive　and　testable　model　of　uterine　activity　that,　in　turn,　informs　the　development　of　new　diagnostic　and　therapeutic　approaches　to　these　pressing　clinical　problems.　This　article　assesses　current　progress　towards　this　goal.　We　summarize　the　electrophysiological　basis　of　uterine　activation　as　presently　understood　and　review　recent　research　approaches　to　uterine　modeling　at　different　scales　from　single　cell　to　tissue,　whole　organ　and　organism　with　particular　focus　on　transformative　data　in　the　last　decade.　We　describe　the　positives　and　limitations　of　these　approaches,　thereby　identifying　key　gaps　in　our　knowledge　on　which　to　focus,　in　parallel,　future　computational　and　biological　research　efforts.