Microencapsulation　of　biological　cells　has　a　broad　range　of　applications　in　pharmacy　and　biomedicine.　This　paper　introduces　generation　of　core-shell　microcapsules　based　on　a　coaxial　electrohydrodynamic　method.　For　the　core　and　shell　materials,　RPMI-1640　culture　medium　and　alginate　are　used　respectively.　The　generated　micro-droplets　become　hydrogel　capsules　with　RPMI-1640　trapped,　by　reacting　with　CaCl2　solution　in　the　collector　electrode.　It　is　found　that　ejection　frequency　can　be　increased　by　either　increasing　the　outer　flow　rate　or　field　strength.　However,　sufficiently　high　outer　flow　rate　or　sufficiently　strong　electric　field　will　change　the　shape　of　the　core　of　the　microcapsule.　Fluorescence　stained　human　peripheral　blood　mononuclear　cells　(PBMC)　are　added　to　RPMI-1640　medium.　Fluorescence　imaging　showed　that　the　cells　are　effectively　encapsulated.　©　2022　IEEE.