Membrane　scaling　represents　one　of　the　significant　challenges　for　membrane　distillation　(MD),　especially　when　treating　hypersaline　brines.　This　work　presents　a　one-step　dip-coating　method　to　develop　an　omniphobic　membrane.　The　commercial　polyvinylidene　fluoride　(PVDF)　hydrophobic　porous　membranes　were　immersed　into　the　epoxy　acrylic　(EA)　resin　and　fluorosilane　(1H,1H,2H,2H-Perfluorodecyltrimethoxysilane,　PFTS)　mixture　followed　by　a　heating　cross-linking　process.　EA/PFTS　ratio　of　1:1　(v/v)　gave　the　best　performance　regarding　surface　morphology,　surface　chemical　composition,　surface　energy,　and　mechanical　property.　The　resultant　PVDF-(EA/PFTS)-1:1　membrane　demonstrated　excellent　wetting　resistance　and　omniphobicity　during　the　penetration　of　deionized　water,　30%　and　60%　ethanol　in　water,　and　kerosene,　giving　141°,　124°,　106°,　and　116°　contact　angles,　respectively.　It　also　exhibited　excellent　scaling　resistance　in　concentrating　14.7　mM　gypsum　solution　and　actual　reverse　osmosis　(RO)　brine.　The　permeate　flux　and　conductivity　were　maintained　at　about　14　kg　m−2　h−1　and　below　3　μS　cm−1,　respectively.　More　than　99%　salt　rejection　(actual　RO　brine)　was　achieved　during　a　long-term　continuous　MD　operation　for　80　h.　The　PVDF-(EA/PFTS)-1:1　membrane　exhibited　excellent　anti-scaling　and　anti-wetting　properties.　A　series　of　capillary　experiments　confirmed　that　the　membrane＇s　surface　pores　achieved　the　gas-wetting　state.　The　increase　in　the　membrane　surface　hydrophobicity,　the　reduction　in　the　surface　pore　size,　and　the　toughening　of　the　surface　pores　contributed　to　the　formation　of　a　stable　gas-liquid　interface　on　the　modified　membrane　surface　that　can　enhance　the　anti-scaling　and　anti-wetting　performance.　©　2022　Elsevier　B.V.