A　RTHT　framework　based　on　LABVIEW-MATLAB-GPU　is　established,　which　uses　graphics　processor　(GPU)　instead　of　the　traditional　central　processing　unit　(CPU)　as　the　hardware　for　numerical　solution.　Taking　a　soil-structure　interaction　system　as　an　example,　the　performance　of　the　testing　framework　is　verified　through　numerical　simulation　and　RTHT　testing.　The　testing　and　simulation　results　demonstrate　that　the　proposed　RTHT　framework　allows　numerical　substructure　with　27000　DOFs　to　be　solved　in　real　time,　hence　that　the　application　range　of　RTHT　is　expanded　significantly　by　the　calculation　capacity　of　GPU.　©　2022,　Editorial　Board　of　Journal　of　Vibration　Engineering.　All　right　reserved.