In　the　aftermath　of　an　earthquake,　damage　to　buildings　and　transportation　networks　severely　affects　post-earthquake　emergency　rescue　and　medical　health　care　services.　This　paper　presents　a　quantitative　framework　considers　seismic　damage　to　buildings　and　transportation　networks,　post-earthquake　available　numbers　of　patient　beds　and　medical　staff　to　evaluate　post-earthquake　health　care　service　accessibility.　The　modified　two-step　floating　catchment　area　method　and　seismic　fragility　analysis　are　integrated　into　the　proposed　framework.　Spatial　distributions　of　demand　point,　hospital,　and　transportation　network　data　are　used　to　evaluate　health　care　service　accessibility.　The　accessibility　results　for　a　medium-sized　city　under　normal　conditions　and　post-earthquake　conditions　are　analyzed　as　a　case　study.　Demand　points　that　lack　access　to　health　care　service　can　be　clearly　delineating　from　the　findings,　indicating　that　large　earthquakes　will　dramatically　impact　people’　normal　health　care　service　accessibility.　The　results　of　this　work　may　provide　a　workable　basis　for　planners　and　policy　makers　to　pragmatically　select　health　care　facility　sites.　©　2022　Elsevier　Ltd