Aiming　at　the　high　cost　of　quantum　equipment　and　the　difficulty　of　preparing　discrete　variable　quantum　states,　a　measurement-device-independent　continuous　variable　semi-quantum　key　distribution　(MDI-CV-SQKD)　protocol　is　proposed.　We,　respectively,　give　the　prepared-measure　model　and　the　entanglement-based　(EB)　model　of　the　MDI-CV-SQKD　protocol.　Based　on　the　EB　model,　we　analyze　the　secret　key　rate　and　other　performance　of　the　protocol　and　perform　numerical　simulations.　Then　we　analyze　the　amount　of　information　transmitted　by　the　channel　under　different　attacks.　As　long　as　the　channel　parameters　meet　certain　conditions,　secure　communication　can　be　carried　out.　Through　parameter　adjustment,　the　solution　can　achieve　the　maximum　secret　key　rate.　The　protocol　has　the　advantages　of　easy　preparation　of　continuous　variables　quantum　states,　low　cost　of　semi-quantum　user　equipment,　and　high　utilization　of　full　quantum　users.　It　also　has　characteristics　such　as　the　unconditional　security　of　the　full　quantum　protocol,　the　resistance　to　the　detector　side-channel　attack　of　the　measurement-device-independent　protocol,　and　the　extension　of　the　transmission　distance.　Therefore,　this　protocol　has　important　practical　value.　©　2022,　The　Author(s),　under　exclusive　licence　to　Springer　Science+Business　Media,　LLC,　part　of　Springer　Nature.