Meteorological　and　human　factors　during　the　specific　epidemic　are　critical　for　effectively　evaluating　the　causes　of　air　quality　changes　in　different　areas.　This　study　selected　Xingtai　City,　Hebei　Province　as　the　research　object,　took　2020　epidemic　situation　as　an　experimental　scenario　of　extreme　emission　reduction　under　the　extreme　control　measures,　and　2021　epidemic　situation　as　an　experimental　analysis　scenario　of　future　normalized　epidemic　prevention　and　control.　Compared　with　the　period　prior　to　the　epidemic,　the　ozone　concentration　during　the　two　epidemics　increased,　and　the　particle　concentration　during　the　2021　epidemic　also　increased.　The　concentration　of　other　pollutants　during　the　2020　epidemic　decreased　to　varying　degrees.　Compared　with　the　same　period　in　2019,　the　ozone　concentration　during　the　two　epidemics　also　increased.　In　addition,　the　pollutant　concentration　during　the　2021　epidemic　declined　more.　Using　LSTM　algorithm　and　WRF-CMAQ　model　to　quantify　impacts　of　meteorological　factors　on　the　changes　in　pollutant　concentration　during　the　two　epidemic　periods.　The　human-induced　changes　in　different　pollutant　concentrations　were　deduced　as　indicated　by　the　results　from　the　air　quality　simulation.　The　simulation　of　LSTM　algorithm　during　the　two　outbreaks　shows　that　human　being　had　a　negative　impact　on　pollutants　(reducing　their　concentration)　and　accounted　for　a　high　proportion　in　the　total　change,　while　the　influence　of　meteorological　factors　simulated　with　CMAQ　model　was　much　higher　than　that　with　LSTM　algorithm.　Anthropogenic　influences　dominated　during　the　2020　epidemic　period,　while　compared　to　that　during　the　2020　epidemic　period,　the　impact　of　anthropogenic　activities　on　pollutants　(except　NO2)　was　positive　(promoting　an　increase　in　pollutant　concentration)　during　the　2021　epidemic　period.　©　2022　Chinese　Society　for　Environmental　Sciences.　All　rights　reserved.