Massive　diagnostic　testing　has　been　performed　for　appropriate　screening　and　identification　of　COVID-19　cases　in　the　ongoing　global　pandemic.　However,　the　environmental　impacts　of　COVID-19　diagnostics　have　been　least　considered.　In　this　paper,　the　environmental　impacts　of　the　COVID-19　nucleic　acid　diagnostics　were　assessed　by　following　a　full　cradle-to-grave　life-cycle　approach.　The　corresponding　life-cycle　anthology　was　established　to　provide　quantitative　analysis.　Moreover,　three　alternative　scenarios,　i.e.,　material　substitution,　improved　waste　treatment,　and　electric　vehicle　(EV)-based　transportation,　were　further　proposed　to　discuss　the　potential　environmental　mitigation　and　conservation　strategies.　It　was　estimated　that　the　life　cycle　of　a　single　COVID19　nucleic　acid　diagnostic　test　in　China　would　lead　to　the　emission　of　612.9　g　CO2　equiv　global　warming　potential.　Waste　treatment,　as　a　step　of　life　cycle,　worsen　the　environmental　impacts　such　as　global　warming　potential,　eutrophication,　and　ecotoxicity.　Meanwhile,　diesel-driven　transportation　was　considered　as　the　major　contributor　to　particulate　air.　Even　though　COVID-19　diagnostics　are　of　the　greatest　importance　to　end　the　pandemic,　their　environmental　impacts　should　not　be　ignored.　It　is　suggested　that　improved　approaches　for　waste　treatment,　low　carbon　transportation,　and　a　reliable　pool　sampling　strategy　are　critical　for　the　achievement　of　sustainable　and　green　diagnostics.