For　guided　bone　regeneration　(GBR)　in　clinical　orthopedics,　the　importance　of　a　suitable　scaffold　which　can　provide　the　space　needed　for　bone　regeneration　and　simultaneously　promotes　the　new　bone　formation　cannot　be　overemphasized.　Due　to　its　excellent　biocompatibility,　mechanical　strength,　and　similarity　in　structure　and　composition　to　natural　bone,　the　mineralized　collagen-based　scaffolds　have　been　increasingly　considered　as　promising　GBR　scaffolds.　Herein,　we　propose　a　novel　method　to　fabricate　an　in-situ　mineralized　homogeneous　collagen-based　scaffold　(IMHCS)　with　excellent　osteogenic　capability　for　GBR　by　electrospinning　the　collagen　solution　in　combination　with　essential　mineral　ions.　The　IMHCS　exhibited　homogeneous　distribution　of　apatite　crystals　in　electrospun　fibers,　which　helped　to　achieve　a　significantly　higher　tensile　strength　than　the　pure　collagen　scaffold　(CS)　and　the　scaffold　with　directly　added　nano-hydroxyapatite　particles　(HAS).　Furthermore,　the　IMHCS　had　significantly　better　cell　compatibility,　cell　migration　ratio,　and　osteogenic　differentiation　property　than　the　HAS　and　CS.　Therefore,　the　IMHCS　not　only　retains　traditional　function　of　inhibiting　fibroblast　invasion,　but　also　possesses　excellent　osteogenic　differentiation　property,　indicating　a　robust　alternative　for　GBR　applications.