With　the　development　of　Moore＇s　law,　the　future　trend　of　devices　will　inevitably　be　shrinking　and　integration　to　further　achieve　size　reduction.　The　emergence　of　new　two-dimensional　non-layered　materials　(2DNLMs)　not　only　enriches　the　2D　material　family　to　meet　future　development,　but　also　stimulates　the　global　enthusiasm　for　basic　research　and　application　technologies　in　the　2D　field.　Van　der　Waals　(vdW)　heterostructures,　in　which　two-dimensional　layered　materials　(2DLMs)　are　physically　stacked　layer　by　layer,　can　also　occur　between　2DLMs　and　2DNLMs　hybrid　heterostructures,　providing　an　alternative　platform　for　nanoelectronics　and　optoelectronic　applications.　Here,　we　outline　the　recent　developments　of　2DLMs/2DNLMs　hybrid　heterostructures,　with　particular　emphasis　on　major　advances　in　synthetic　methods　and　applications.　And　the　categories　and　crystal　structures　of　2DLMs　and　2DNLMs　are　also　shown.　We　highlight　some　promising　applications　of　the　heterostructures　in　electronics,　optoelectronics,　and　catalysis.　Finally,　we　provide　conclusions　and　future　prospects　in　the　2D　materials　field.