In　recent　years,　metal　organic　frameworks　(MOFs)　have　attracted　increasing　attention　in　cancer　therapy,　because　they　can　enhance　the　anticancer　efficacy　of　photodynamic　therapy　(PDT),　photothermal　therapy　(PTT),　photoacoustic　imaging,　and　drug　delivery.　Owing　to　stable　chemical　adjustability,　MOFs　can　be　used　as　carriers　to　provide　excellent　loading　sites　and　protection　for　small-molecule　drugs.　In　addition,　MOFs　can　be　used　to　combine　with　a　variety　of　therapeutic　drugs,　including　chemotherapeutics　drugs,　photosensitizers,　and　radiosensitizers,　to　efficiently　deliver　drugs　to　tumor　tissue　and　achieve　desired　treatment.　There　is　hardly　any　review　regarding　the　application　of　MOFs　in　hepatocellular　carcinoma.　In　this　review,　the　design,　structure,　and　potential　applications　of　MOFs　as　nanoparticulate　systems　in　the　treatment　of　hepatocellular　carcinoma　are　presented.　Systematic　Review　Registration:　website,　identifier　registration　number　Copyright　©　2022　Feng,　Wu　and　Li.