Metal-organic　frameworks　(MOFs),　a　crystalline　porous　material　with　a　periodic　net-work　structure　formed　by　the　self-assembly　of　transition　metal　ions　and　organic　ligands,　have　been　widely　applied　in　various　fields　due　to　their　rich　composition　and　structural　diversity.　Among　vari-ous　types　of　MOFs,　stimuli-responsive　MOFs　have　gained　increasing　attention　in　recent　years,　because　of　their　broad　application　in　the　field　of　physics,　biology,　and　chemistry.　In　this　review,　we　analyzed　and　classified　the　mechanism　of　stimulus-response　MOFs　(pH　response,　glucose　response,　GSH　response,　light　response,　temperature　response)　and　their　applications　in　drug　delivery,　adsorption　and　luminescence　functions,　magnetization　and　catalysis　functions,　probe　and　sensor.