A　deep　understanding　of　explosive　sensitivities　and　their　factors　is　important　for　safe　and　reliable　ap-plications.However,quantitative　prediction　of　the　sensitivities　is　difficult.Here,reactive　molecular　dy-namics　simulation　models　for　high-speed　piston　impacts　on　explosive　supercells　were　established.Simulations　were　also　performed　to　investigate　shock-induced　reactions　of　various　high-energy　explo-sives.The　fraction　of　reacted　explosive　molecules　in　an　initial　supercell　changed　linearly　with　the　propagation　distance　of　the　shock-wave　front.The　corresponding　slope　could　be　used　as　a　reaction　rate　for　a　specific　shock-loading　velocity.Reaction　rates　that　varied　with　the　shock-loading　pressure　exhibited　two-stage　linearities　with　different　slopes.The　two　inflection　points　corresponded　to　the　initial　and　accelerated　reactions,which　respectively　correlated　to　the　thresholds　of　shock-induced　ignition　and　detonation.Therefore,the　ignition　and　detonation　critical　pressures　could　be　determined.The　sensitivity　could　then　be　a　quantitative　prediction　of　the　critical　pressure.The　accuracies　of　the　quantitative　shock　sensitivity　predictions　were　verified　by　comparing　the　impact　and　shock　sensitivities　of　common　ex-plosives　and　the　characteristics　of　anisotropic　shock-induced　reactions.Molecular　dynamics　simulations　quantitatively　predict　and　rank　shock　sensitivities　by　using　only　crystal　structures　of　the　explosives.Overall,this　method　will　enable　the　design　and　safe　use　of　explosives.