Carbon　monoxide　(CO)　is　a　toxic　and　harmful　gas　pollutant.　The　realization　of　low-temperature　CO　oxidation　has　been　the　focus　of　research.　Also,　CO　oxidation　as　a　typical　model　reaction　is　conducive　to　the　in-depth　study　of　the　catalytic　reaction　mechanism.　Due　to　its　unique　oxygen　storage/release　capacity　(OSC)　and　the　easy　transition　between　Ce3(+)　and　Ce4(+),　CeO2　is　widely　used　as　a　catalyst　and　catalyst　support　in　many　important　reactions,　especially　the　low-temperature　CO　oxidation　reaction.　Herein,　the　application　of　cerium-based　materials　in　low-temperature　CO　oxidation　and　CeO2　activity　enhancement　strategies　in　recent　years　are　elaborated　upon,　including　metal　loading,　adjustment　of　exposed　facets　of　CeO2,　and　metal　doping,　through　metal-support　interaction　and　the　generation　of　oxygen　vacancies　on　the　CeO2　surface　to　improve　the　CO　oxidation　activity　of　cerium-based　catalysts.　At　the　end　of　the　review,　the　synthesis　of　Ce-based　materials　and　their　applications　and　challenges　in　the　field　of　CO　oxidation　are　looked　at.