The　compositions　of　volatile　organic　compounds　(VOCs)　under　actual　industrial　conditions　are　often　complex;　especially,　the　interaction　of　intermediate　products　easily　leads　to　more　toxic　emissions　that　are　harmful　to　the　atmospheric　environment　and　human　health.　Herein,　we　report　a　comparative　investigation　on　1,2-dichloroethane　(1,2-DCE)　and　(1,2-DCE　+　toluene)　oxidation　over　the　Ru/TiO2,　phosphotungstic　acid　(HPW)-modified　Ru/TiO2,　and　oxygen　vacancy-rich　Ru/TiOx　catalysts.　The　doping　of　HPW　successfully　introduced　the　1,2-DCE　adsorption　sites　to　promote　its　oxidation　and　exhibited　outstanding　water　resistance.　For　the　mixed　VOCs,　Ru/HPW-TiO2　promoted　the　preferential　and　superfluous　adsorption　of　toluene　and　resulted　in　the　inhibition　of　1,2-DCE　degradation.　Therefore,　HPW　modification　is　a　successful　strategy　in　catalytic　1,2-DCE　oxidation,　but　Brionsted　acid　sites　tend　to　adsorb　toluene　in　the　mixed　VOC　oxidation.　The　Ru/TiOx　catalyst　exhibited　excellent　activity　and　stability　in　the　oxidation　of　mixed　VOCs　and　could　inhibit　the　generation　of　byproducts　and　Cl-2　compared　with　the　Ru/HPW-TiO2　catalyst.　Compared　with　the　Brionsted　acid　modification,　the　oxygen　vacancy-rich　catalysts　are　significantly　suitable　for　the　oxidation　of　multicomponent　VOCs.