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Author:

Xu, Xinze (Xu, Xinze.) | Lin, Lan (Lin, Lan.) | Sun, Shen (Sun, Shen.) | Wu, Shuicai (Wu, Shuicai.)

Indexed by:

Scopus SCIE

Abstract:

Alzheimer's disease (AD) is a degenerative disorder that leads to progressive, irreversible cognitive decline. To obtain an accurate and timely diagnosis and detect AD at an early stage, numerous approaches based on convolutional neural networks (CNNs) using neuroimaging data have been proposed. Because 3D CNNs can extract more spatial discrimination information than 2D CNNs, they have emerged as a promising research direction in the diagnosis of AD. The aim of this article is to present the current state of the art in the diagnosis of AD using 3D CNN models and neuroimaging modalities, focusing on the 3D CNN architectures and classification methods used, and to highlight potential future research topics. To give the reader a better overview of the content mentioned in this review, we briefly introduce the commonly used imaging datasets and the fundamentals of CNN architectures. Then we carefully analyzed the existing studies on AD diagnosis, which are divided into two levels according to their inputs: 3D subject-level CNNs and 3D patch-level CNNs, highlighting their contributions and significance in the field. In addition, this review discusses the key findings and challenges from the studies and highlights the lessons learned as a roadmap for future research. Finally, we summarize the paper by presenting some major findings, identifying open research challenges, and pointing out future research directions.

Keyword:

Alzheimer's disease convolution neural network computer-aided diagnosis deep learning

Author Community:

  • [ 1 ] [Xu, Xinze]Beijing Univ Technol, Fac Environm & Life Sci, Intelligent Physiol Measurement & Clin Translat, Dept Biomed Engn,Beijing Int Platform Sci & Techno, Beijing 100124, Peoples R China
  • [ 2 ] [Lin, Lan]Beijing Univ Technol, Fac Environm & Life Sci, Intelligent Physiol Measurement & Clin Translat, Dept Biomed Engn,Beijing Int Platform Sci & Techno, Beijing 100124, Peoples R China
  • [ 3 ] [Sun, Shen]Beijing Univ Technol, Fac Environm & Life Sci, Intelligent Physiol Measurement & Clin Translat, Dept Biomed Engn,Beijing Int Platform Sci & Techno, Beijing 100124, Peoples R China
  • [ 4 ] [Wu, Shuicai]Beijing Univ Technol, Fac Environm & Life Sci, Intelligent Physiol Measurement & Clin Translat, Dept Biomed Engn,Beijing Int Platform Sci & Techno, Beijing 100124, Peoples R China

Reprint Author's Address:

  • [Lin, Lan]Beijing Univ Technol, Fac Environm & Life Sci, Intelligent Physiol Measurement & Clin Translat, Dept Biomed Engn,Beijing Int Platform Sci & Techno, Beijing 100124, Peoples R China;;

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Source :

REVIEWS IN THE NEUROSCIENCES

ISSN: 0334-1763

Year: 2023

Issue: 6

Volume: 34

Page: 649-670

4 . 1 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

ESI HC Threshold:13

Cited Count:

WoS CC Cited Count: 14

SCOPUS Cited Count: 17

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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