There　is　very　limited　research　on　the　application　of　moderate　halophiles　for　biotreatment　of　hypersaline　wastewater　widely　generated　from　some　industries.　This　study　demonstrated　the　development　of　moderate　halophiles　inoculated　from　saltern　sediments　into　aerobic　granule　sludge　(AGS)　to　treat　hypersaline　wastewater　with　a　salinity　of　100　g/L.　The　granulation　of　moderate　halophiles　can　occur　without　applying　the　settling　ve-locity　selective　pressure.　The　saltern　sediment　initially　aggregated　into　single　small　granules　and　finally　devel-oped　into　1200　+/-　50　mu　m　multiparticle　granules.　The　halophiles　affiliated　in　Halomonas　was　dominant　in　the　granular　bacterial　community,　with　a　relative　abundance　of　94.52%.　Halomonas　ventosae　secreted　sulfated　polysaccharides.　The　sulfated　polysaccharides　content　accounted　for　63.95　+/-　2.10%　in　the　polysaccharides　(PS),　having　an　adhesive　role　in　connecting　single　granules.　Multiparticle　granules　showed　the　clear　stratified　struc-ture,　with　alpha-D-glucopyranose　polysaccharides　in　the　inner　bounders　and　beta-D-glucopyranose　polysaccharides　in　the　outer.　The　moderately　granular　sludge　showed　the　stable　chemical　oxygen　demand　(COD)　removal　efficiency　of　＞90%　and　the　aerobic　total　inorganic　nitrogen　(TIN)　removal　efficiency　(equal　to　ammonia　removal)　of　70　+/-　5.00%.　This　paper　contributes　new　insight　into　the　formation　of　moderately　halophilic　granular　sludge　and　accelerates　the　application　of　moderately　halophilic　granular　sludge　to　treat　hypersaline　wastewater.