The　overall　management　of　multi-stakeholders　in　the　supply　chain,　such　as　consumers,　collectors,　dismantling　enterprises,　etc.,　is　the　core　way　to　guide　regions　with　different　levels　of　development　to　form　a　synergy　of　e　-waste　utilization.　Based　on　the　complex　system　theory,　this　study　evaluates　e-waste　flow　trends　in　regions　with　different　levels　of　development,　and　constructs　a　regional　e-waste　synergistic　utilization　model.　We　employ　Guangdong　Province,　the　most　typical　urban-rural　dual　structure,　as　a　case　study　and　explore　the　interplay　of　stakeholders　in　the　supply　chain　and　strategies　for　synergistic　utilization　of　e-waste.　It　is　found　that　e-waste　in　the　developed　areas　will　spontaneously　flow　to　areas　where　dismantling　and　utilizing　are　highly　concentrated.　And　stakeholders　influence　the　e-waste　recycling　chain　in　terms　of　e-waste　dismantling　and　utilizing　and　regional　environmental　performance.　The　simulation　results　show　that　Guangdong　Province　will　still　have　a　large　demand　for　e-waste　treatment,　and　the　regional　environmental　loss　will　be　obvious　in　2030.　Furthermore,　we　construct　three　policy　scenarios:　strengthening　responsibility　extension,　regional　joint　prevention　and　regional　collabo-rative　innovation.　Under　the　policy　combination,　the　formal　dismantling　rate　increases　by　38.6%　and　the　environmental　performance　loss　ratio　decreases　by　18%,　and　the　policies　have　a　significant　catalytic　effect.　We　further　analyze　the　role　of　the　establishment　of　an　extended　responsibility　system　for　producers　and　consumers,　a　reverse　supply　chain　traceability　system　and　a　regional　green　circular　supply　chain　system　to　promote　the　co-ordinated　development　of　e-waste.