In　this　paper,　the　mechanical　properties　of　carbon　fibre　reinforced　multidirectional　laminates　at　different　temperatures　were　tested.　Based　on　the　consideration　of　the　microstructure　and　fibre　layer　thickness　of　the　multidirectional　laminates,　a　stress　normalized　method　is　proposed.　Based　on　the　normalized　static　ultimate　strength　and　fatigue　stress,　a　life　prediction　model　suitable　for　the　fatigue　process　dominated　by　compression　damage　is　proposed　at　high　temperature.　The　fatigue　test　results　at　different　temperatures　showed　that　the　proposed　fatigue　life　prediction　model　considering　the　strength　contribution　of　different　orientation　fibre　layers　and　the　degradation　of　matrix　properties　at　high　temperature　can　successfully　predict　the　fatigue　life　of　multidirectional　laminates　at　different　temperatures,　and　the　life　prediction　error　is　within　the　range　of　three　factors.