The　sustainable　economic　development　of　the　Yangtze　River　Economic　Belt　is　a　significant　part　of　China＇s　regional　development　strategy.　The　article　selects　panel　data　from　11　provinces　of　the　region　from　2004　to　2020　and　constructs　a　spatial　economic　model　and　a　threshold　effect　model　to　investigate　the　impact　of　energy　development　and　technological　innovation　on　the　real　economy　of　this　region.　The　result　indicates　that　technological　innovation　plays　a　significantly　beneficial　role　in　supporting　the　development　of　the　local　real　economy,　while　its　spatial　spillover　effect　to　neighboring　provinces　is　not　significant.　Energy　development　has　a　significant　negative　impact　on　both　the　local　real　economy　and　that　of　the　neighboring　provinces.　Such　impact　is　shaped　by　the　threshold　effect　of　the　level　of　technological　innovation.