Several　studies　have　elucidated　the　link　between　outdoor　noise　and　depression,　but　the　relationship　between　indoor　noise　levels　and　depression　symptoms　in　residential　and　public　places　remains　unclear.　This　study　was　a　multicenter　observational　study　with　a　cross-sectional　design.　In　2019,　a　total　of　10　545　indoor　noise　levels　on-site　and　26　018　health　data　from　practitioners　were　collected　from　2402　hotels　in　111　cities.　Indoor　daily　noise　data　levels　were　detected,　and　PHQ-9　questionnaires　were　used　to　collect　health　data.　Logistic　analysis　was　used　to　determine　the　association　between　depression　score　and　noise　level,　negative　binomial　regression　was　used　to　determine　potential　risks.　The　geometric　mean　indoor　noise　level　was　38.9　dB　(A),　with　approximately　40.9%　of　hotels　exceeding　the　45　dB　value　(A).　Approximately　19.1%　of　hotel　workers　exhibited　mild　and　above　depressive　symptoms.　In　addition　to　functional　zoning,　geographic　location,　central　air　conditioner,　decoration　status,　and　other　factors　had　an　impact　on　noise　levels　(p　＜　0.05).　Results　of　logistic　and　negative　binomial　regression　showed　the　following:　(1)　there　was　significantly　positive　association　between　indoor　noise　and　high　depression　scores　above　2　(OR　=　1.007,　95%　CI:　1.002,　1.012)　and　(2)　some　sub-groups　were　more　susceptible　to　this　effect,　especially　for　the　younger　female　workers　working　in　the　first-tier　cities,　having　higher　education　level,　lower　level　of　income,　smoking,　and　longer　working　hours.　This　study　confirms　an　early　potential　effect　of　indoor　noise　on　depression.　It　is　recommended　to　implement　evidence-based　measures　to　control　noise　sources　in　hotels.