This　paper　presents　a　series　of　test　investigations　and　finite　element　(FE)　analyses　on　the　compressive　behaviors　of　cold-formed　steel　(CFS)　compression　members　with　web　holes　of　different　widths　and　the　corresponding　direct　strength　design　method　is　proposed.　In　the　test　investigations,　a　total　of　twenty　specimens　were　tested　under　axial　compression　loading　with　five　different　hole　width-to-web　width　ratios　of　0,　0.2,　0.4,　0.6,　and　0.8.　It　is　shown　that　the　local　buckling　deformations　for　specimens　with　web　holes　occur　in　the　vicinity　of　web　holes　and　decrease　as　the　hole　widens.　For　the　axial　capacities　of　specimens,　they　are　decreased　by　11.7%　on　average　with　the　increase　of　hole　width-to-web　width　ratio　from　0　to　0.4　while　they　are　decreased　by　31.5%　on　average　with　the　increase　of　hole　width-to-web　width　ratio　from　0.4　to　0.8.　In　the　FE　studies,　the　FE　models　for　CFS　compression　members　with　web　holes　of　different　widths　were　developed　using　the　ANSYS　program.　The　simulation　results　show　that　the　compressive　behaviours　obtained　from　FE　analyses　are　in　good　agreement　with　test　results.　Then,　combined　with　test　data,　a　total　of　412　FE　parametric　analyses　were　conducted　to　predict　the　proportional　re-lationships　between　the　axial　capacities　of　compression　members　with　web　holes　and　those　without　web　holes,　and　the　hole　impact　coefficient　formulas　were　correspondingly　derived　which　differ　from　the　previous　re-searcher＇s　contribution.　Based　on　the　hole　impact　coefficient　formulas　and　the　direct　strength　method　(DSM)　of　CFS　compression　members　without　web　holes　in　AISI　S100-2016,　the　DSM　formulas　of　CFS　compression　members　with　web　holes　were　developed,　in　which　the　elastic　critical　buckling　stress　of　CFS　compression　members　with　web　holes　was　not　necessary　to　be　calculated.