Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression - Details

Author：

Indexed by：

EI Scopus SCIE

Abstract：

Cervical　squamous　cell　carcinoma　(CESC)　is　a　prototypical　human　cancer　with　well-characterized　pathological　stages　of　initiation　and　progression.　However,　high-resolution　knowledge　of　the　transcriptional　programs　underlying　each　stage　of　CESC　is　lacking,　and　important　questions　remain.　We　performed　single-cell　RNA　sequencing　of　76,911　individual　cells　from　13　samples　of　human　cervical　tissues　at　various　stages　of　malignancy,　illuminating　the　transcriptional　tumorigenic　trajectory　of　cervical　epithelial　cells　and　revealing　key　factors　involved　in　CESC　initiation　and　progression.　In　addition,　we　found　significant　correlations　between　the　abundance　of　specific　myeloid,　lymphoid,　and　endothelial　cell　populations　and　the　progression　of　CESC,　which　were　also　associated　with　patients’　prognosis.　Last,　we　demonstrated　the　tumor-promoting　function　of　matrix　cancer–associated　fibroblasts　via　the　NRG1-ERBB3　pathway　in　CESC.　This　study　provides　a　valuable　resource　and　deeper　insights　into　CESC　initiation　and　progression,　which　is　helpful　in　refining　CESC　diagnosis　and　for　the　design　of　optimal　treatment　strategies.　Copyright　©　2023　The　Authors,　some　rights　reserved.

Keyword：

Author Community：

[ 1 ] [Liu C.]Department of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China
[ 2 ] [Liu C.]Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, 250117, China
[ 3 ] [Zhang M.]Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China
[ 4 ] [Yan X.]Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, 100124, China
[ 5 ] [Ni Y.]State Key Laboratory of Experimental Hematology, Senior Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China
[ 6 ] [Gong Y.]State Key Laboratory of Experimental Hematology, Senior Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China
[ 7 ] [Wang C.]Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China
[ 8 ] [Zhang X.]Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China
[ 9 ] [Wan L.]Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, 100124, China
[ 10 ] [Yang H.]Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, 100124, China
[ 11 ] [Ge C.]Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, 100124, China
[ 12 ] [Li Y.]State Key Laboratory of Experimental Hematology, Senior Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China
[ 13 ] [Zou W.]Department of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China
[ 14 ] [Huang R.]Department of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China
[ 15 ] [Li X.]Department of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China
[ 16 ] [Sun B.]Department of Radiation Oncology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China
[ 17 ] [Liu B.]State Key Laboratory of Experimental Hematology, Senior Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China
[ 18 ] [Yue J.]Department of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China
[ 19 ] [Yu J.]Department of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China
[ 20 ] [Yu J.]Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, 250117, China

Reprint Author's Address：

Email：

Show more details

Related Keywords：

Source ：

Science Advances

ISSN： 2375-2548

Year： 2023

Issue： 4

Volume： 9

1 3 . 6 0 0

JCR@2022

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 58

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 6

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS

Type
Departments

All Years Choose Year From to