In　RC　flat　plate　structures,　slab-column　joints　play　a　key　role　in　transferring　the　gravity　load　from　the　slabs　to　the　columns　due　to　the　absence　of　beam　elements.　If　one　or　more　columns　of　a　flat　plate　structure　are　damaged　in　an　accidental　event,　the　load　redistribution　process　may　trigger　punching　shear　failures　at　the　adjacent　slab-column　joints.　Progressive　collapse　of　a　large　portion　of　the　structure,　or　even　its　entirety,　is　like　to　occur　following　punching　failure　propagations.　Given　that　progressive　collapse　is　a　dynamic　phenomenon,　investigating　the　dynamic　responses　of　the　structure　under　sudden　column　removal　scenarios　are　imperative.　In　this　study,　a　high-fidelity　numerical　model　is　developed　to　simulate　the　dynamic　behavior　of　a　multi-panel　flat　plate　substructure　under　a　sudden　removal　of　an　interior　column.　The　model　is　validated　by　three　sequential　experimental　tests　on　the　same　substructure,　by　which　the　load　responses　of　the　interior　column　stub,　the　slab　deflections　and　the　crack　patterns　are　verified.　Based　on　the　validated　model,　the　dynamic　load　redistribution　patterns　of　the　three　tests　are　evaluated.　Two　series　of　parametric　studies　are　also　conducted　to　investigate　the　influence　of　the　load　level　on　the　slab　overhangs　and　the　load　release　speed　on　the　slab　deflections.　©　2022　the　Author(s).