A　series　of　catalysts　with　different　cobalt　loadings　were　prepared　using　dendritic　mesoporous　silica　nanospheres　(DMSNs)　as　carriers　by　the　isovolume　impregnation　method.　The　physicochemical　properties　of　the　catalysts　were　characterized　with　XRD,　SEM,　TEM,　BET,　H2-TPR,　O2-TPD,　XPS,　EPR　and　Raman,　and　the　catalytic　oxidation　activity　of　the　catalysts　towards　toluene　and　their　stability　were　investigated.　The　results　show　that　the　prepared　cobalt-based　DMSNs　catalysts　have　a　high　specific　surface　area　and　ordered　mesoporous　structure,　which　are　beneficial　to　the　dispersion　of　active　components　and　the　contact　between　active　sites　and　reactants.　With　the　increase　of　Co　loading,　the　activity　of　catalyst　shows　a　trend　of　increasing　first　and　then　decreasing.　Among　them,　10%Co/DMSNs　catalyst　shows　the　best　catalytic　activity　when　the　temperature　(T90)　is　up　to　268　at　the　toluene　conversion　rate　of　90%　(under　the　mass　space　velocity　of　15000　mL/(g·h)　and　the　initial　toluene　concentration　of　50　μL/L),　and　also　exhibits　excellent　water　resistance　and　stability.　The　active　component　of　the　catalyst　is　mainly　in　the　form　of　Co2+,　which　possesses　more　oxygen　vacancies　and　highly　reactive　oxygen　species,　and　thus　can　facilitate　the　catalytic　oxidation　of　toluene.　The　special　morphological　structure　of　the　carrier　and　the　strong　interaction　between　the　cobalt　oxygen　species　and　the　carrier　have　improved　the　catalyst　stability.　©　2022　Science　Press.　All　rights　reserved.