Regional　reference　frames　are　the　critical　geodetic　infrastructure　for　realizing　high-accuracy　crustal　deformation　and　long-term　landslide　monitoring.　According　to　the　published　results　in　active　tectonic-block　zonation　and　long-term　GNSS　observations,　the　authors　divide　China　into　seven　“rigid-frame　blocks”　(or　“rigid　blocks”)　and　intend　to　establish　the　stable　regional　reference　frame　series　covering　the　entire　land　and　sea　areas　of　China:　Northeast,　North,　South,　Northwest,　Qinghai-Tibet,　Sichuan-Yunnan,　and　South　China　Sea　reference　frames.　This　article　introduces　the　method　for　realizing　the　coordinate　transformation　from　the　global　reference　frame　(IGS14)　to　regional　reference　frames　and　exemplifies　the　applications　of　the　North　China　Reference　Frame　(NChina20)　and　the　South　China　Reference　Frame　(SChina20)　in　long-term　landslide　monitoring　and　initial　slide　automatic　detection.　©　2022　SinoMaps　Press.　All　rights　reserved.