To　investigate　the　seismic　response　of　a　prefabricated　metro　station　in　different　site　conditions,　a　three-dimensional　static　and　dynamically-coupled　nonlinear　finite　element　model　of　a　prefabricated　metro　station　is　established　based　on　finite　element　software.　Then,　the　seismic　response　of　the　fabricated　metro　station　under　different　site　conditions,　peak　accelerations　of　seismic　waves,　and　vertical　seismic　waves　is　systematically　analyzed.　Finally,　the　acceleration,　deformation,　stress,　and　plastic　damage　laws　of　the　fabricated　metro　station　are　obtained.　The　results　demonstrate　that:　(1)　The　horizontal　displacement　difference　between　top　and　bottom　of　the　station　structure　and　the　opening　angles　of　the　joint　gradually　increase　as　the　site　conditions　change　from　category　Ⅱ　to　category　Ⅲ,　and　the　growth　rate　gradually　increases,　but　the　opening　angles　of　the　joint　are　maintained　at　a　low　level　(less　than　0.10°),　verifying　the　stability　and　safety　of　the　joint.　(2)　The　waist　and　shoulder　of　the　top　arch　and　the　envelope　structure　near　the　sidewall　are　prone　to　plastic　damage　in　site　condition　category　Ⅲ.　(3)　Compared　with　single-horizontal　seismic　waves,　the　deformation,　stress,　opening　angles　of　joint,　and　plastic　damage　of　the　fabricated　metro　station　will　be　significantly　increased　by　increasing　the　horizontal　seismic　waves.　Generally,　under　site　condition　category　Ⅱ　and　an　input　peak　acceleration　of　seismic　waves　of　0.1g　and　0.2g,　the　structure　is　basically　in　a　flexible　working　state;　whereas　under　site　condition　category　Ⅲ　and　an　input　peak　acceleration　of　a　seismic　wave　of　0.4g,　the　prefabricated　metro　station　is　in　a　plastic　working　state　and　the　area　of　the　plastic　zone　is　large.　©　2022,　Editorial　Office　of　Tunnel　Construction.　All　rights　reserved.