Bone　drilling　is　a　standard　surgical　procedure.　High　drilling　temperature　can　reduce　the　biological　activity　of　bone　tissue,　cause　thermal　damage,　and　possibly　reduce　drilling　quality.　This　study　was　based　on　the　simulation　of　the　surgical　drilling　process　with　the　finite　element　method　(FEM).　The　drilling　temperature　was　predicted　through　the　response　surface　method　(RSM)　and　obtained　the　minimum　temperature　and　its　corresponding　drilling　parameter　combination.　In　this　study,　residual　and　variance　analyses　were　performed　on　the　drilling　temperature　prediction　model　and　proved　that　the　model　fitting　effect　was　good　and　the　reliability　was　high.　Furthermore,　this　study　analyzed　the　influence　trend　of　three　parameters　affecting　drilling　temperature:　drill　diameter,　rotational　speed,　and　feeding　speed.　It　has　a　specific　reference　value　for　orthopedic　clinical　surgery.　©　Published　under　licence　by　IOP　Publishing　Ltd.