To　investigate　the　alterations　in　structural　integrity　of　white　matter　fiber　tracts　with　temporal　lobe　epilepsy　(TLE)　patients,　diffusion　tensor　imaging　(DTI)　and　structural　magnetic　resonance　imaging　(sMRI)　were　performed　on　23　TLE　patients　and　30　healthy　controls　subjects.　The　fractional　anisotropy　(FA),　mean　diffusivity　(MD),　axial　diffusivity　(AD)　and　radial　diffusivity　(RD),　fiber　density　(FD),　fiber　cross-section　(FC)　and　fiber　density　and　cross-section　(FDC)　were　measured　and　compared　between　the　two　groups　by　using　the　voxel-based　analysis　(VBA)　and　fixel-based　analysis　(FBA)　methods.　Additionally,　the　correlation　between　white　matter　alterations　and　the　duration　of　disease　were　analyzed.　Compared　with　the　healthy　controls　group,　the　MD,　AD　and　RD　values　of　TLE　patients　increased;　the　FA,　FD,　FC　and　FDC　values　were　reduced.　Results　show　that　FBA　of　magnetic　resonance　DTI　provides　a　new　method　to　show　the　alterations　of　white　matter　fiber　tracts　in　the　whole　brain　morphological,　which　is　helpful　for　the　diagnosis　of　TLE.　©　2022,　Editorial　Department　of　Journal　of　Beijing　University　of　Technology.　All　right　reserved.