Case　history　investigations　have　shown　that　pile　foundations　are　more　critically　damaged　in　liquefiable　soils　than　non-liquefiable　soils.　This　study　examines　the　differences　in　seismic　response　of　pile　foundations　in　liquefiable　and　non-liquefiable　soils　and　their　sensitivity　to　numerical　model　parameters.　A　two-dimensional　finite　element　(FE)　model　is　developed　to　simulate　the　experiment　of　a　single　pile　foundation　centrifuge　in　liquefiable　soil　subjected　to　earthquake　motions　and　is　validated　against　real-world　test　results.　The　differences　in　soil-pile　seismic　response　of　liquefiable　and　non-liquefiable　soils　are　explored.　Specifically,　the　first-order　second-moment　method　(FOSM)　is　used　for　sensitivity　analysis　of　the　seismic　response.　The　results　show　significant　differences　in　seismic　response　for　a　soil-pile　system　between　liquefiable　and　non-liquefiable　soil.　The　seismic　responses　are　found　to　be　significantly　larger　in　liquefiable　soil　than　in　non-liquefiable　soil.　Moreover,　the　pile　bending　moment　was　mainly　affected　by　the　kinematic　effect　in　liquefiable　soil,　while　the　inertial　effect　was　more　significant　in　non-liquefiable　soil.　The　controlling　parameters　of　seismic　response　were　PGA,　soil　density,　and　friction　angle　in　liquefiable　soil,　while　the　pile　bending　moment　was　mainly　controlled　by　PGA,　the　friction　angle　of　soil,　and　shear　modulus　of　loose　sand　in　non-liquefiable　soil.