Catalytic　properties　of　multiple　metals　deposited　on　TiO2　nanoparticles　were　investigated　in　the　oxidation　of　toluene.　Isovolume　impregnation　method　prepared　the　catalysts　containing　Cu,　Mn,　Ni,　Co,　and　Fe　deposited　on　TiO2,　including　CeO2　and　ZrO2.　The　effects　of　loaded　metal　oxides　on　the　structure　and　activity　of　initial　catalysts　were　investigated　using　various　characterization　techniques.　Toluene＇s　removal　efficiency　and　CO2　selectivity　in　the　catalyst　system　were　classified　as　follows:　CuCeZr/T　＞　MnCeZr/T　＞　NiCeZr/T　＞　CoCeZr/T　＞　FeCeZr/T.　Presence　of　water　vapor　exhibits　an　inhibitory　effect　on　the　conversion　of　toluene,　which　diminishes　at　higher　temperatures.　One　contribution　of　this　paper　is　to　obtain　the　oxidation　pathway　of　toluene　and　the　relationship　between　the　activation　energy　of　all-inclusive　and　elementary　reactions　based　on　the　variation　of　infrared　spectrum　using　Freeman-Carroll　method.　Another　contribution　is　to　clarify　the　share　of　Langmuir-Hinshelwood　and　Mars-van　Krevelen　mechanisms　during　the　oxidation　of　toluene　over　CuCeZr/T　catalyst　by　transient　response　experiments　of　isotopically　labeled　oxygen.　These　findings　provide　a　feasible　method　for　the　design　and　synthesis　of　transition　metal　oxide　catalysts　for　industrial　applications.