Inorganic　perovskite　quantum　dots　(PQDs)　have　been　regarded　as　attractive　materials　in　various　optoelectronic　fields　due　to　their　excellent　optical　properties,　however,　the　high　sensitivity　to　moisture,　temperature　and　radiation　has　put　a　limit　for　their　real　long-term　application,　and　a　more　stable　host　is　indispensable.　CsPbBr3　PQDs　with　high　stability　and　excellent　luminescence　properties　are　successfully　embedded　in　tellurite-based　glasses　by　one-step　melting　and　subsequent　heat　treatment.　Pure　cubic　structure　PQDs　with　the　radius　of　2.5–5.5　nm　are　proved　to　disperse　evenly　in　the　glass　matrix.　Thermal　and　cold　cycles,　long-term　radiation　and　humidity　exposure　have　illustrated　its　stability　and　confirmed　the　effectiveness　of　the　designed　glass　system.　The　high　photoluminescence　intensity,　wide　wavelength　tunability　of　470–508　nm　and　narrow　band-width　emission　of　31.8–36.6　nm　with　the　tunable　optical　band　gap　2.44–2.51　eV　have　demonstrated　its　excellence　as　the　optoelectronic　materials.　These　results　demonstrate　that　CsPbBr3　PQDs　embedded　in　tellurite　glass　matrix　can　overcome　existing　instability　limitation　and　provide　full　potential　of　PQDs　in　practical　photonic　and　opto-electronic　applications.　©　2023　Elsevier　B.V.