Indoor　thermal　comfort　is　essential　as　it　improves　living　standards.　Activity　scenarios　of　personnel　are　in　the　process　of　a　dynamic　change.　In　most　interior　spaces　with　fixed　working　stations,　people　directly　blown　by　cold　air　have　a　poor　thermal　experience.　Therefore,　to　meet　the　differentiated　environmental　demands,　one　challenge　is　to　explore　novel　ventilation　strategies　to　satisfy　the　changing　environmental　needs.　An　adaptive　strategy,　multi-vent　module-based　adaptive　ventilation　(MAV),　was　designed　to　increase　the　adjustability　of　air　distribution　and　better　adapt　to　variable　demands.　A　classroom　was　chosen　as　a　representative　model　with　multiple　scenarios　during　its　use.　Simulations　were　conducted　to　verify　the　three-level　control　effect　of　MAV　on　improving　the　thermal　environment.　The　results　revealed　that　different　vent　solutions　create　different　airflow　patterns　and　thermal　environments,　which　can　be　matched　to　the　scenarios.　The　scale　for　ventilation　efficiency　No.　4,　which　measured　the　influence　scope　of　supply　air,　was　used　to　evaluate　the　zoning　division　control　in　MAV.　The　space　under　the　charge　of　a　concerned　MAV　module　showed　a　higher　SVE4　than　that　at　other　zones.　This　implied　that　the　zoning　division　can　be　effectively　implemented.　Thermal　comfort　measured　using　the　air　diffusion　performance　index,　predicted　mean　vote,　and　draught　rate　showed　that　the　application　of　MAV　is　better　than　that　of　the　fixed　MV　mode,　and　the　discomfort　experienced　when　exposed　to　cold　air　can　be　avoided.　It　is　believed　that　these　results　will　help　extend　the　research　of　adaptive　ventilation　strategies.　©　2023,　Tsinghua　University　Press.